Well I can't think of anyone else in FFX that may classify as the main antagonist. Seymour doesn't count because he's a scrub by the end of his arc, the Yevon dude is a dude we basically don't know the entire game. I think Jecht is the best candidate as the main villain of the game, and he was cool.
Well, the biggest conflicts in Final Fantasy X go side by side. Tidus' father issues with Jecht and Jecht being Sin, who is destroying Spira and its inhabitants; those point to Jecht being the major villain. Granted, Seymour had caused a lot of trouble for Tidus, Yuna, and the rest, it all goes back to Jecht/Sin. Oh, and Sin is one hideous fiend, so I guess "it" would be the ugliest villain.