No ways, I couldn't bring myself to do it, even on a disposable save. I had to watch it on youtube instead. While I like playing RPGs, and assuming a role, I could never go Chaotic Evil.
I've only nuked them once.. just to see how it would turn out, because I wanted to see where it would lead story-wise and what I would get. But generally no, I tend to avoid nuking megaton. It's just too terrible for me to handle.