For me it was bum rushing a enforcer using the aa-12 style shotgun nearly took all my heath but I killed him then managing to get to cover and kill his friends without dieing.
Completed the story twice and did a lot of sidequests, but I honestly can't remember one thing I've done that was awesome
Almost beating the story and most of the side quests before having Uplay delete my saves. That was fun.
-Starting the story over again, only to find that I didn't get to keep my old save's weapons and skills, I had to get them all over again from the start. That was fun too.